Genetics and Pharmacogenomics Takes Center Stage at Personalized Medicine World Conference 2010

January 20, 2010

Yesterday was the first day of Personalized Medicine World Conference, Silicon Valley.

The most surprising part of the line up of 13 speakers is that 9 of them talked about genetics or pharmacogenomics, topics that would have been mentioned briefly, if at all, even 5 years ago. The promise of personalized medicine is that we will be able to determine from someone’s DNA which drugs are appropriate in what dose to be effective.

A good deal of the focus was on how to handle genetic information in a clinical setting, with doctors who may not have the training in genetics.

Another theme for the talks was the decreasing cost of getting genetic information on a patient and how this can drive clinical decisions. The ultimate dream is to be able to test a patient’s genetic data, get an almost instantaneous read out and treat appropriately.

Some highlights:

  1. Scott Jenkins, Ph.D. from Dell Healthcare & Life Sciences talked about the challenge of storing a terabyte of DNA data per patient and the challenge that presents.
  2. Russ Altman, Ph.D. showed off his web PharmGKB project curating and cataloging pharmacogenomic data. Vance Vanier, MD of Navigenics talked very frankly about how in order for genetic data to be useful, it must be brought into clinical practice.
  3. Elizabeth Mansfield, Ph.D. spoke about the changes happening at the FDA surrounding regulations as it pertains to personalized medicine, in her words, “Policies were not written with personalized medicine in mind, we are trying to find the best pathway forward.”

Looking forward to the more consumer/patient talks today.


Video: IBM Claims Mobile Collaboration Crown At Lotusphere

January 19, 2010

In a quite unusual way, IBM “officially” pre-announced tomorrow’s news at a “Nachos and News” event for bloggers only!

This is the second time Big Blue is pre-briefing bloggers over nachos and “weak” beers. I wish they did that for day 1 announcements which were a lot more interesting: project Vulcan, LotusLive cloud offering, etc.

My guess is that feeding bloggers with second-grade announcements ahead of traditional media for day 3 is not much of a big deal.

Anyway, it was also a great opportunity to mingle with some of the people behind Projet Vulcan, which is nice. More on Vulcan on a later post with our conversation with IBM Fellow Carol Jones.

IBM to surpass Microsoft and Google mobile collaboration with Android, iPhone, Nokia, RIM deals

As for the news, as I said earlier, not much excitement aside from a messaging mobility announcement.

“IBM, with those partnerships and RIM, has the strongest messaging collaboration mobility story on the market. In the past we’ve been deemed to be a follower in a lot of these things and I would assert that we are actually ahead of the game now with the completeness of support for Quikr, Connections and Sametime across multiple devices and the fullness of things like encrypted mail support on mobile devices. Nobody is doing that as a base service. You have to go to third parties to get there with Exchange or Google, or anybody else”, said Notes guru Ed Brill.

Below, a video excerpt of the very casual “nachos and news” event.


Lotusphere: IBM Vulcan Set To Redefine Collaboration

January 19, 2010

IBM kicks off Lotusphere 2010 with Vulcan, dubbed as the next-generation collaboration tool!

I’m here blogging from Orlando, Florida, attending Lotusphere, Lotus’ flagship annual customers and partners conference.

The day started slowly, with me fuming over the enervating and complete disorganization of Lotus blogger program, like handing out bloggers their interview schedule at the very last minute. I got mine less than an hour before my first interview. Neat!

Anyway, things got much better as the day goes by, with 6 more 30-minutes briefings in less than 3 hours!

The big news today at Lotusphere is a project called Vulcan, which IBM Lotus claims to be the “blueprint for the future of collaboration.”

More on Vulcan, as well as Lotus Live (a cloud solution), Symphony (Lotus’ free office suite), IBM client for Smart Work (with a netbook offering) and a behind-the-scene Lotus Knows’ marketing campaign in later posts.


High Cost Batteries Could Limit The Spread Of Electric Cars, One Study Says. But Is This So?

January 19, 2010

The hype behind electric cars is, well, high energy.

Yet sales of these save-the-earth vehicles could be seriously constrained by the high cost of batteries. So says a study by the Boston Consulting Group. But not all carmakers are buying into the conclusion.

Some argue rapidly expanding production volumes will significantly lower the costs of batteries for electric cars

Most automakers appear to be planning on advanced batteries that will cost as little as $250 a kilowatt-hour of energy. But achieving that goal by 2020 will be a stretch without a major breakthrough in battery technology, according to the study co-written by analyst Xavier Mosquet.

Battery costs will fall over the next decade, and already lithium ion offers a lighter, more powerful alternative to the nickel-metal hydride battery in the Toyota Prius.

However, today’s prices of $1,000 to $1,200 a kWh may not reach the $250 to $500 a kWh level, the study finds. Carmakers seem focused on this lower price level because it is close to the $250 to $400 per kWh cost of lithium ion batteries used in consumer electronics. Yet consumer electronics batteries are simpler than car batteries and have less demanding requirements in terms of lifespan and safety, says Boston Consulting Group. Prices of auto batteries may not fall this far.

Some carmakers are hesitant to draw the same conclusion. Greg Frenette, manager of global electrified fleets at Ford, says a major technological breakthrough would be useful, but might not be necessary.

Battery production will increase dramatically over the decade, and prices will fall significantly as the manufacturing lines expand, he says. By Boston Consulting Group’s own estimate, the market will reach $25 billion by 2020, or triple the size of the today’s consumer market for lithium ions.

“I think volume can have a significant impact on overall cost,” says Frenette. For electric carmakers, the metric will be a key one to follow.


More Protectionism In China Could Distort Polysilicon Prices For Solar Cells

January 19, 2010

Polysilicon prices fell in 2009 to one tenth of what they were two years ago as a glut of new capacity came online. They are likely to tumble further.

Producers had just begun to emerge in recent months from the numbing days of the downturn, when sales and profits plunged. Now this recovery is threatened by government policies in China, which are keeping the discipline of a free market from taking hold.

Chinese government makes investments in polysilicon makers

According to Lux Research, the Chinese government stepped in to prop up key polysilicon manufacturers with cash late last year. This should shield them continued price declines and allow them to expand plants if they wish, or keep unneeded ones operating.

Publicly, Chinese officials have warned domestic suppliers they have too much manufacturing capacity. But the recent actions run counter to the warning and appear to make some sort of accommodation unnecessary. The country had the capacity to produce 50,000 tons of polysilicon at the end of 2009, or more than 80 percent of projected worldwide demand for 2010.

Despite the call for companies to scale back production, the government took aggressive steps to put more financial resources in company hands.

In November, Jiangxi International Trust and Investment, an arm of the Xinyu provincial government, bought a 15 percent stake of an LDK Solar plant for $219 million. The same month, GCL Silicon sold a 20 percent stake of the company to the China Investment Corp., a state-sponsored investment house.

The investments come only several months after the country imposed import restrictions to keep local prices from falling too fast.

Clearly the country hopes to manipulate the market to favor its companies, If the world wants a free market in polysilicon – and more realistic prices – its needs to confront government subsidies and protectionism in China.


Clean Tech, An Optimistic Point Of View

January 18, 2010

Sure, 2009 was a tough year for clean tech, with demand for solar panels sinking, venture money cut in half and corporate buyers turning into nervous Nellies.

Speculation that IPOs from Tesla Motors, Solyndra, Silver Springs and others could define 2010

True, the Obama Administration began stimulating the industry with billions in research and development funds. But even this was criticized by those who think the government should have no role in private industry. (Of course, these naysayers conveniently forget government money help create the Internet. But that is another topic.)

So why does one venture capitalists believe 2010 could be a breakout year for some categories of clean tech? On his blog, Green Gold, Access Venture Partners lead clean tech Partner David Gold says some green tech companies are showing success generating revenue and profits. At the same time, the IPO market is heating up. This year could see the first significant wave of clean tech public offerings, he predicts.

On the government front, cap and trade legislation in the U.S. could create a favorable backdrop by increasing the price of fossil fuel-based energy sources.

Gold singles out companies such as EnerNoc, Comverge and Cree as examples of green business with exciting revenue growth and improving profitability.

“I can say that our own LED lighting portfolio company, TerraLux, not only had exceptional revenue growth but also showed its first period of positive cash flow,” he wrote.

As the year unfolds, several high profile clean tech companies could launch IPOs, adds Gold, including Tesla Motors, Silver Springs Networks, Solyndra and Codexis, which makes biofuels.

Should a string of successful IPOs come about, other businesses would rush to catch the tail winds. And that would suddenly make clean energy more real for average Americans who continue to think going green doesn’t mean them.


Price Of LED Lighting Seen Matching Incandescent Products In 2 Years

January 18, 2010

Light-emitting diodes are more energy efficient than the incandescent bulbs still widely sold around the world – and more expensive.

The price of an LED lighting chip will fall to $1 by 2012, says Mark McClear of Cree.

This higher price could evaporate within two years, sparking a huge market for the electricity saving bulbs and light fixtures.

LEDs use as little as one-fifth the energy of incandescent bulbs and 12 percent less than compact fluorescents. (They also have none of the mercury found in compact fluorescents.)

But the costs of solid-state lighting come to $40 or so a bulb, and fixtures are much more. This is down from $80 or more a bulb just a year ago. By 2012 the price of an LED chip appropriate for lighting could fall to $1 from about $3 today, closing the gap, says Mark McClear, director of business development at Cree. Fixtures equivalent in intensity to incandescent products on the market today will need 100 chips to generate the same amount of light. Their price will be about the same.

The price of LED chips has fallen as brightness increased, McClear said at the Strategic Materials Conference in Half Moon Bay, CA.

Not long ago, 400 chips were needed, at $4 a piece, with the cost of the resulting fixture too high to be competitive. Improvements in light intensity have made that 200 today at $2 a piece.

With technology continuing to improve, the lighting market is on the cusp of a dramatic transformation with energy efficiency the force behind new business and consumer purchases.


AlertMe To Broaden Smart Grid Product Line In Early 2010, Hopes For Key US Pilot

January 18, 2010

Million of venture dollars have gone into smart grid startups in a frenzy of interest over turning energy conservation into a business.

So far, smart meters have been the big money maker, with giant utilities anointing the winners. It may finally be time for smaller players to get their due.

AlertMe expects to add a thermostat monitor early this year to its product family

One smaller player facing a critical 2010 is the British based AlertMe out of Cambridge. The company has a heritage in the British home security market, but will strengthen its smart energy product line in the first half of the year by roll out a key addition. The company also anticipates its first U.S. pilot in the space.

AlertMe creates an in-home energy-monitoring network with a series of devices connected to a wireless hub. The devices report the energy use of office equipment and other appliances, and let homeowners create home energy profiles.

Then, so the reasoning goes, they can adjust their habits to save energy and money.

So far it is not clear how interested consumers will be in micromanaging their energy use. But David Bercovich, vice president of business development, says the company is finding success with an early wave of English customers who have purchased products off the AlertMe Web site.

They automatically set home policies to turn off peripherals when they leave home, he says. The system also helps detect appliances that are malfunctioning and burning too much energy. In early 2010, the company will bring out a thermostat link that will let people adjust heat and cooling settings for when they are away.

“A lot of (home energy conservation) is am information problem,” Bercovich says. AlertMe, which has raised venture capital funding from the likes of Vantage Point and Index Ventures, hopes to solve it.


Energy Dept Wants US To Lead LED Lighting Market But The Odds Are Long

January 15, 2010

Energy Department Secretary Steven Chu wants the U.S. to be the global leader in the emerging market for energy efficient LED and OLED lighting.

There is no guarantee. Big companies from around the world have the market in their sites, including consumer electrics giants Sharp, Toshiba and Philips.

On Friday, Chu hoped to put more wood behind his arrow by awarding stimulus act funding to 14 companies. It was the department’s third round of funding for solid-state lighting and the first to include manufacturing projects.

Departmetn Of Energy allocates another $37 million in stimulus funds to LED lighting

Still, the more than $37 million he allocated is a drop in the bucket. The $100 billion a year lighting market will bring much larger private investments from firms eager to secure places in such as lucrative business,

The Department of Energy money will go to 17 projects, with the majority ($23.5 million) slated for manufacturing efforts.  Ten million dollars is to be used for product development and $4 million is earmarked for research. Private funds of $28.5 million are being invested alongside the government money.

Among the companies collecting money are GE, Applied Materials, KLA Tencor, Ultratech, Veeco, Cree, Osram Sylvania and Cambios. The University of Rochester also is to get a research grant.

Also on the list is Philips Lumileds, a division of the Dutch company Koninklijke Philips Electronics.

Chu said the stakes behind LED and OLED bulbs and lighting are high. Lighting consumes a quarter of the nation’s electricity and solid-state products could cut that use by one third.

But foreign competitors will be angling for a piece of the pie as well. Earlier this month, Sharp and Toshiba said they will begin shipping products into the U.S. this spring. Other well heeled companies (perhaps Samsung) are expected to enter the market as well.

In addition, many of the top LED chip producers are in Asia. In other words, the U.S. has its work cut out for itself.


Fisker Raises Another $115M As Money Continues To Pour In

January 15, 2010

Fisker continues to make news. Thursday, the company announced it selected lithium ion batteries from A123 for its Karma plug-in hybrid electric sports car.

Fisker recharges its bank account with more money from private investors including Kleiner Perkins

Friday it unveiled $115.3 million in new private equity funding. Among the investors is white-shoe venture firm Kleiner Perkins Caufield & Byers, a previous Fisker backer.

The company said the money was necessary to qualify for $528.7 million in federal loan guarantees awarded by the Department of Energy in October. Both financings will hasten the completion of the Karma, its first car. Shipments are expected later this year with a price tag starting at $87,900. The first year production run is anticipated to be 15,000 vehicles.

Along with Kleiner Perkins, A123 participated in the funding round. A123 said Thursday it had invested $23 million into the company, $13 million in cash and $10 million in stock.

A third investor was ACE Investments. No other backers were released.

“Raising $115 million in these times speaks volumes about the value of our business model and the vast potential of plug-in hybrids,” said Fisker CEO Henrik Fisker.

Fisker was formed in 2007 and is headquartered in Southern California while rival Tesla Motors is in Northern California. In October, it bought a General Motors production plant in Wilmington, DE, where it plans to make is second car, the Nina, beginning in late 2012.


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